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This effect was attributed to the inhibition of the Shh signaling pathway, leading to the suppression of Shh and Bcl-2 expression, inhibition of the nuclear translocation of Gli1, and increase of caspase-3 cleavage 20 (Figure 1)

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In addition, pomegranate juice enhanced mitochondrial respiration and, at higher concentrations, suppressed glycolytic activity while simultaneously inhibiting cell proliferation

doi: 10.1186/s12944-022-01671-5